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Nurse Practitioner Salary in San Francisco, California

Updated 2026-04-05BLS 2024 data — be the first to add a local report

Salary Distribution

BLS 2024
$230,658/ year

Median Nurse Practitioner in San Francisco, CA

$147,149
10th
$179,450
25th
$230,658
Median
$290,450
75th
$354,349
90th

Compensation Breakdown

BLS 2024
Base salary (median)
$230,658
Total compensation (est.)
$265,257
Bonus range
$4,850 – $18,840
Mean salary
$244,497

How This Compares

San Francisco, CA median
$230,658
California median
$127,174+81.4%
National median
$124,680+85.0%

Cost of living in San Francisco is 85% above the national average. Salary of $230,658 here is equivalent to $124,680 nationally.

Salary by Experience

0-2 years
$166,074-28.0%
3-5 years
$209,899-9.0%
6-10 years
$258,337+12.0%
10+ years
$318,308+38.0%

Salary by Company Size

Startup (< 100 employees)
$202,979-12.0%
Mid-size (100–5,000)
$230,658
Enterprise (5,000+)
$272,176+18.0%

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Nurse Practitioner Salaries in Nearby Cities

Los Angeles, CA$188,267/yr
San Diego, CA$179,539/yr
San Jose, CA$221,930/yr
Fresno, CA$124,680/yr
Sacramento, CA$124,680/yr

Related Jobs in San Francisco

Registered Nurse$150,257/yr
Physician Assistant$233,119/yr
Physical Therapist$180,782/yr
Occupational Therapist$172,383/yr
Pharmacist$245,588/yr

Quick Numbers

Hourly (40hr week)$111/hr
Monthly gross$19,222/mo
25th percentile$179,450/yr
75th percentile$290,450/yr

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Market Context

via FRED

Fed Funds Rate

Mar 2026

3.64%

Inflation (CPI)

year-over-year

2.4%+0.04

National Unemployment

Mar 2026

4.3%-0.10

California Unemployment

Dec 2025

5.5%-0.10

Avg Hourly Earnings

all private workers

$37.38+$0.09

10yr Treasury

Apr 2026

4.31%

Source: St. Louis Fed (FRED). Updated daily.

Nurse Practitioner Salaries by City

Compare all US cities →

Frequently Asked Questions

What is the average Nurse Practitioner salary in San Francisco?

The median Nurse Practitioner salary in San Francisco is $230,658 per year, with a range from $179,450 at the 25th percentile to $290,450 at the 75th percentile. Total compensation including bonuses typically runs higher — see the breakdown above for the full picture.

How does Nurse Practitioner pay in San Francisco compare to the national average?

Nurse Practitioner salaries in San Francisco are 85% above the national median of $124,680. After adjusting for San Francisco's cost of living, the purchasing power of that salary is equivalent to roughly $124,680 nationally — which is the number that actually matters when comparing offers across cities.

What factors affect Nurse Practitioner salaries in San Francisco?

In San Francisco, the biggest drivers are years of experience, company size, and industry vertical. Entry-level Nurse Practitioner roles start around $147,149, while senior and staff-level positions at larger employers can reach $354,349 or above. Specialized skills and in-demand tools can also meaningfully shift where you land in the range.

Is San Francisco a good place for Nurse Practitioner jobs?

San Francisco offers a Nurse Practitioner median of $230,658, which is 85% above the US median of $124,680. Whether that makes it a good market depends on your personal cost-of-living equation — San Francisco is 85% more expensive than the national average, so factor that into your math.

How do I negotiate a higher Nurse Practitioner salary?

Start with the data on this page: the 75th percentile for Nurse Practitioner in San Francisco is $290,450, which is a defensible anchor for a negotiation. Come in with a specific number backed by real market data — not a range — and reference your experience tier. If you're above the median, ask for the 75th percentile. If you're already at the 75th, push for total comp improvements like equity or bonus instead.