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Physician Assistant Salary in St. Louis, Missouri

Updated 2026-04-05BLS 2024 data — be the first to add a local report

Salary Distribution

BLS 2024
$112,149/ year

Median Physician Assistant in St. Louis, MO

$70,061
10th
$85,440
25th
$112,149
Median
$139,730
75th
$170,471
90th

Compensation Breakdown

BLS 2024
Base salary (median)
$112,149
Total compensation (est.)
$128,971
Bonus range
$4,800 – $18,840
Mean salary
$118,878

How This Compares

St. Louis, MO median
$112,149
Missouri median
$128,530-12.7%
National median
$126,010-11.0%

Cost of living in St. Louis is 11% below the national average. Salary of $112,149 here is equivalent to $126,010 nationally.

Salary by Experience

0-2 years
$80,747-28.0%
3-5 years
$102,056-9.0%
6-10 years
$125,607+12.0%
10+ years
$154,766+38.0%

Salary by Company Size

Startup (< 100 employees)
$98,691-12.0%
Mid-size (100–5,000)
$112,149
Enterprise (5,000+)
$132,336+18.0%

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Physician Assistant Salaries in Nearby Cities

Kansas City, MO$114,669/yr
Springfield, MO$126,010/yr
Columbia, MO$126,010/yr
Independence, MO$126,010/yr

Related Jobs in St. Louis

Registered Nurse$72,286/yr
Nurse Practitioner$110,965/yr
Physical Therapist$86,971/yr
Occupational Therapist$82,930/yr
Pharmacist$118,148/yr

Quick Numbers

Hourly (40hr week)$54/hr
Monthly gross$9,346/mo
25th percentile$85,440/yr
75th percentile$139,730/yr

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Market Context

via FRED

Fed Funds Rate

Mar 2026

3.64%

Inflation (CPI)

year-over-year

2.4%+0.04

National Unemployment

Mar 2026

4.3%-0.10

Missouri Unemployment

Dec 2025

3.9%-0.10

Avg Hourly Earnings

all private workers

$37.38+$0.09

10yr Treasury

Apr 2026

4.31%

Source: St. Louis Fed (FRED). Updated daily.

Physician Assistant Salaries by City

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Frequently Asked Questions

What is the average Physician Assistant salary in St. Louis?

The median Physician Assistant salary in St. Louis is $112,149 per year, with a range from $85,440 at the 25th percentile to $139,730 at the 75th percentile. Total compensation including bonuses typically runs higher — see the breakdown above for the full picture.

How does Physician Assistant pay in St. Louis compare to the national average?

Physician Assistant salaries in St. Louis are 11% below the national median of $126,010. After adjusting for St. Louis's cost of living, the purchasing power of that salary is equivalent to roughly $126,010 nationally — which is the number that actually matters when comparing offers across cities.

What factors affect Physician Assistant salaries in St. Louis?

In St. Louis, the biggest drivers are years of experience, company size, and industry vertical. Entry-level Physician Assistant roles start around $70,061, while senior and staff-level positions at larger employers can reach $170,471 or above. Specialized skills and in-demand tools can also meaningfully shift where you land in the range.

Is St. Louis a good place for Physician Assistant jobs?

St. Louis offers a Physician Assistant median of $112,149, which is 11% below the US median of $126,010. Whether that makes it a good market depends on your personal cost-of-living equation — St. Louis is 11% cheaper than the national average, so factor that into your math.

How do I negotiate a higher Physician Assistant salary?

Start with the data on this page: the 75th percentile for Physician Assistant in St. Louis is $139,730, which is a defensible anchor for a negotiation. Come in with a specific number backed by real market data — not a range — and reference your experience tier. If you're above the median, ask for the 75th percentile. If you're already at the 75th, push for total comp improvements like equity or bonus instead.